Xanax Interaction with OTC Drugs and Beverages

Xanax Interaction with OTC Drugs and Beverages

Xanax(Alprazolam) falls into the category of prescribed drugs, which means you need a prescription to buy the drug. Remember well and bear in mind that taking Xanax with Over the Counter (OTC) drugs might be a fatal error. The American Journal of Forensic Medicine and Pathology states that death rate of people taking Xanax alone is rare. The statistic of 178 postmortem examination shows that 87 deaths were caused by mixing Xanax with another drug against the two caused by using Xanax alone.

Below are some of the Xanax/Alprazolam interaction with commonly used OTC Drugs and beverages like

  • Xanax interaction with Benadryl (Diphenhydramine)
  • Xanax interaction with Tylenol (Acetaminophen)
  • Xanax interaction with Caffeine (Tea, Coffee)
  • Xanax interaction with Alcohol


Diphenhydramine belongs to a class of drugs called antihistamine. Diphenhydramine is used for the treatment of cold and flu symptoms mostly followed by treating hay fever, insomnia, and allergies. Diphenhydramine aids a person to relax and doze off by blocking histamine and acetylcholine in the body.

Xanax (Alprazolam)is a benzodiazepine which works by binding to the GABA receptors in the brain and the central nervous system by lowering anxiety and causing the mind to be calm


When used together, the action of Xanax and Diphenhydramine multiply to produce side effects like drowsiness, concentration deficiency, dizziness, and confusion. Impairment in judgment and thinking, as well as poor motor coordination, is observed in elderly people.


XANAX INTERACTION WITH Darvocet Propoxyphene/Acetaminophen

Propoxyphene is a narcotic analgesic; it works as a pain reliever and cough suppressant by stimulating opioid receptors.

Acetaminophen is an analgesic (pain reducing) and antipyretic (fever reducing) drug. It is marketed under Tylenol and is a part of different brands. (Click here for complete list).

It reduces the prostaglandin production and acts on the brain temperature regulator to minimize pain and temperature respectively.



When Xanax and Darvocet are used together, they cause side-effects like concentration difficulty, nausea, sleepiness, and confusion. Both these medications should be strictly taken as per doctor’s prescription.


Caffeine belongs to a methylxanthine class and is used as CNS stimulant. It is the most widely consumed, legal, and unregulated drug available all around the world. It is mostly consumed in the form of coffee, capsule, and powder.

Caffeine Interaction with Xanax:

A large dose of Caffeine or people with low caffeine threshold is bound to experience caffeine jitters, increased nervousness and anxiety. These caffeine actions interfere with Xanax effects nullifying them completely. The Caffeine and Xanax interaction is backed by the study published in the journal Toxicology in Vitro proving that Caffeine interaction is adverse with benzodiazepine drugs.

Read the detailed scientific research.


Xanax Interaction with Alcohol

When Xanax is taken with alcohol, the effects of Xanax are multiplied like the euphoria and intense relaxation caused due to the action of GABA. When combined, increased GABA activity is observed which causes over-sedation. These heightened feeling will cause the person to abuse Xanax with alcohol, and he will be prone to the following side effects:

Vertigo, fainting, drowsiness, slurred speech, unsteady gait, impaired coordination, low pulse, shallow breathing, nausea, irritability and impaired memory, stupor and finally coma due to respiratory depression.

Do not start or stop using any medications without first consulting your doctor or licensed Health practitioner.

If you find any friend or colleague in trouble due to Xanax and Alcohol. Please Click here for more information


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